The common uses of finesteride are in treatment of BPH (Benign Prostatic Hyperplasia) and alopecia or baldness. Benign Hyperplasia Prostate is a very common problem among elderly men, especially after the age of 55 years. Autopsies done in men in the eighth decade of life, shows the presence of hyperplastic changes (mainly Benign Prostatic Hyperplasia) in more than 90%. From this it can be easily estimated how common Benign Prostatic Hyperplasia in men is.
Every man who is more than 55 years of age should be checked for BPH and diagnosed as early as possible.
Treatment of BPH, include use of 5-alpha reductase inhibitor drugs such as finesteride (brand name is Propecia, Proscar etc.), dutesteride etc. and alpha-adrenergic blockers such as terazosin, prazosin etc.
Finasteride at the dose of 10 mg per day orally and other 5-alpha reductase inhibitors block the conversion of testosterone to dihydrotestosterone which can cause shrinkage of the prostate size, which in turn result in increase urine flow rates, and improve symptoms of Benign Prostatic Hyperplasia. 5-alpha reductase inhibitor drugs help in reversing the disease process by reducing the size of prostate gland in men. 5-alpha reductase inhibitors also lower the baseline PSA (prostatic specific antigen) levels by approximately half. The baseline PSA is important when using PSA as a guide for biopsy recommendations in BPH, to diagnose cancer of prostate.
The alpha-adrenergic blockers such as terazosin at the dose of 1-10 mg per day orally cause relaxation of the smooth muscles of the neck of urinary bladder and increase the peak urinary flow rates, thereby improve the symptoms of BPH, such as difficulty in urination. But the alpha-adrenergic blockers do not have any influence on the progression of the disease and only provide symptomatic relief, unlike 5-alpha reductase inhibitors, which reverses the disease process at least to some extent.