Treatment of Cellulitis

Cellulitis is an acute inflammatory condition of the skin that is characterized by localized pain, redness, swelling, and rise in temperature of that particular area of inflammation. The commonest organisms that cause cellulitis are staphylococcus and streptococcus and they being the commonest organism, the treatment is generally targeted at killing these organisms.

The primary treatment (first line treatment) of cellulitis:

The first line treatment of cellulitis is with newer penicillin. Among newer penicillins Nafcillin or oxacillin at the dose of 2 gram intravenously every 4 to 8 hourly is the drug of choice.

Second line treatment of cellulitis:

Second line treatment of cellulitis is with cephalosporins, other semi-synthetic penicillins or with drugs like erythromycin. Among cephalosporins the drug of choice is Cefazolin, (dose 1 to 2 gram every 8 hourly). Ampicillin + sulbactam (semisynthetic penicillin) or Erythromycin, 0.5 to 1.0 gram intravenously every 6 hourly or Clindamycin, 600–900 mg intravenously every 8 hourly can also be used as second line drug for treatment of cellulitis.

The resistance to antibiotics like erythromycin is a problem in treatment of infections like cellulitis. The frequency of erythromycin resistance in group A Streptococcus is very common and currently approximately 5% in the United States but has reached as high as 70% to 100% in many countries. Most (though not all), erythromycin-resistant group A streptococci are susceptible to clindamycin. Approximately 90% to 95% of Staphylococcus aureus (which also cause cellulitis) strains are sensitive to clindamycin.

Related Posts Plugin for WordPress, Blogger...